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. 2017 Feb 9;8(2):e2603. doi: 10.1038/cddis.2016.352

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Downregulation of MCM7 restrains cell cycle progression by suppressing cyclin D1 expression. (a and b) Cell cycle analysis of HCC cells transfected by Lv-shRNA-MCM7 or Lv-shRNA-Control. (c) A total of 16 cell cycle-related genes were screened after lentiviral vector transduction. (d) Western blot analysis of cyclin D1, CDK4, p27, p21, total RB and p-RB in HCC cells after lentiviral vector transduction. Data are represented as mean±S.E.M. from three independent experiments. *P<0.05; **P<0.01