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. 2017 Feb 2;8(2):e2574. doi: 10.1038/cddis.2016.454

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Nedd4-2 knockdown improves the motor disorder and TH expression in MPTP-treated mice. (a and b) Behavioral tests. Nedd4-2 knockdown prolonged the holding time and shortened the climbing time of MPTP-treated mice. (c) Immunohistochemistry (IHC) staining showing that Nedd4-2 knockdown increases TH expression in the SN in MPTP-treated mice. (d) IHC staining showing that Nedd4-2 knockdown increases TH expression in the striatum in MPTP-treated mice. (e and f) IHC staining showing that Nedd4-2 knockdown attenuates astrogliosis and reactive microgliosis in the SN in MPTP-treated mice. Results are expressed as the mean±S.E. One-way ANOVA. n=12 per group in (a and b); n=6 per group in (c–f). **P<0.01, *P<0.05, ^##P<0.01, ^#P<0.05. *Represents a significant difference between other group and ctrl shRNA group; while ^#represents the significant difference between MPTP+ctrl shRNA and MPTP+Nedd4-2 shRNA group. Scale bar: 100 μm in (c), 50 μm in (d), and 30 μm in (e) and (f)