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. 2017 Feb 23;8(2):e2631. doi: 10.1038/cddis.2017.48

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Lsd1 controls Senescence by Repression of Sirt4. (a–c) Comparison of wild-type (Lsd1^+/+) and Lsd1-deficient (Lsd1^−/−) TSCs transfected with an unrelated or two different siRNAs directed against Sirt4. (a) qRT-PCR of the indicated cell cycle regulators normalized to three housekeeping genes relative to transcription in wild-type TSCs transfected with an unrelated siRNA. (b) Proliferation of TSCs was determined in real time. (c) Quantitative determination of senescent TSCs. (d) Model for the Lsd1-controlled redox balance preventing senescence. Data were analyzed from at least three biological samples and are represented as mean+S.E.M. *P<0.05, ***P<0.001 (unpaired, two-tailed Student's t-test, (a–c))