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. 2017 Feb 2;8(2):e2594. doi: 10.1038/cddis.2017.6

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Intracellular ROS levels were determined in A-375 at 4 h of treatment with 30 μM vemurafenib (Vem), 50 μM TRAM-34 (TRAM), the ROS scavenger vitamin E (VitE; α-tocopherol; 1 mM) and combinations. Examples on the right side demonstrate reduction of high ROS levels through VitE. (b and c) Induction of apoptosis (b) and loss of cell viability (c) were determined at 48 h in response to Vem (30 μM), TRAM (50 μM) and VitE (1 mM). All experiments were performed in triplicates, and at least two independent experiments showed highly comparable results; asterisks indicate statistical significance