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. 2017 Feb 9;8(2):e2600. doi: 10.1038/cddis.2017.9

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Expression of RASAL2 in BCa tissues. (a) Representative pictures of IHC staining of RASAL2 in normal urothelium, papillary urothelial neoplasm of low malignant potential (PUNLMP), low grade/NMIBC and high grade/MIBC. The scale bar represents 100 μm. (b and c) Quantification and percentage analysis of RASAL2 staining in normal urothelium and BCa tissues with different grades (b) and stages (c) were shown. Normal urothelium (NU, n=10), PUNLMP (LMP, n=11), low-grade BCa (LG, n=40), high-grade BCa (HG, n=81), NMIBC (n=66) and MIBC (n=66). (d) Quantification analysis of RASAL2 staining in NMIBC tissues with different grades. (e) Heatmap for IHC of RASAL2 staining in BCa tissues with different grades and stages. *P<0.05, **P<0.01