Table 1. Effect of mouse-related amino-acid transporter deficiency in T-cell fate decision.
| T-cell development | Naive T-cell homeostasis | T-cell activation | T-cell differentiation | T-cell memory | References | |
|---|---|---|---|---|---|---|
| Slc7a5–/– mice | No | No | T-cell activation↓ | Th1 and Th17 cells↓ | Not available | 11 |
| Slc1a5–/– mice | No | (1) For young micea: No (2) For older miceb: CD4+ T cells↓ CD44loCD62Lhi CD4+ T cells↑ | Activation of mTORC1 in T cellsc↓ | Th1 and Th17 cells↓ | (1) For young micea: No (2) For older miceb: Memory CD4+ T cells↓ | 10 |
| Slc6a1–/– mice | No | No | IL-2 secretion and CD69 expression in T cellsc ↑ | Th1 cells↑ | Not available | 9, 71 |
Abbreviations: IL, interleukin; mTORC1, mechanistic target of rapamycin complex 1; no, no effect; not available, the data are missing; Th, T-helper; ↑, increase; ↓, decrease.
a
6–7 weeks.
b
5–6 months.
c
After anti-CD3 and anti-CD28 stimulation.