Table 1. Selectivity of DGBP and zoledronate for malignant versus primary cells.
|
IC50 (μM) (95% CI) |
Selectivity versusPBMC |
||||
|---|---|---|---|---|---|
| PBMC | Molt-4 | Jurkat | Molt-4 | Jurkat | |
| DGBP | 1200 (480–3000) | 15 (4.7–48) | 30 (14–64) | 80 | 40 |
| Zoledronate | 63 (32–120) | 52 (37–74) | 81 (46–140) | 1.2 | 0.78 |
| Fold difference | 0.053 | 3.5 | 2.7 | ||
Abbreviation: DGBP, digeranyl bisphosphonate