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. 2017 Mar 23;8(3):e2701. doi: 10.1038/cddis.2017.121

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The effect of oridonin analogs on the growth of RCC cells. (a) The effect of oridonin analogs on the cell growth of HK-2 KD and 786-0 KD determined by MTT assay. The growth inhibition rate was calculated based on the control. (b) Chemical structure of oridonin and CYD-6-17. (c) The effect of CYD-6-17 on the growth of a variety of RCC cell lines determined by MTT assay. The growth inhibition rate was calculated based on the control. (d) The effect of CYD-6-17 on the growth of HUVEC alone or co-cultured with 786-0 KD cells determined by crystal violet assay with OD 555 nm. *P<0.05