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. 2017 Mar 30;8(3):e2706. doi: 10.1038/cddis.2017.123

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Anti-tumorigenic role of miR-199a-3p. miR-199a-3p expression was compared between (a) HCC tumor and normal liver (NL) tissues, (b) HCC tumor and adjacent non-tumor tissues and (c) HCC cell lines and normal liver (NL). (d) Tumor volume at different time points and (e) tumor weight of subcutaneous HCC in either vector or miR-199a-3p overexpressed cell line injected NOD/SCID mice. (f) Size and number of the nodule formed in the lung after 4 weeks of injection of either vector or miR-199a-3p overexpressed cell line through tail vein in NOD/SCID mice. (g) Hematoxylin and eosin staining of the lung section. Area enclosed by dotted line indicates metastatic growth. *P<0.05, **P<0.01 and ***P<0.005 respectively