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Proposed model for miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer. Foxi1 binds to miR-491 promoter and activates the miR-491-5p expression. miR-491-5p mediates the proliferation inhibition and apoptosis promotion by targeting Wnt3a thereby affects WNT/β-catenin signaling and related downstream molecules in gastric cancer cells
