Figure 4.
The BRCA1 pathway is downregulated in NSCLC cells exposed to TTFields. (a) z-scores and P-values of BRCA1 pathway gene expression along with the relevant pathway gene names. (b) Immunoblot of representative BRCA1 pathway genes demonstrating the downregulation of BRCA1, FANCD2 and FANCA protein levels resulting from TTFields treatment at 72 h. (c) Quantification of BRCA1, FANCD2 and FANCA protein levels from immunoblots (N=3)