Table 2. Evaluation of radiosensitization effect of TTFields in combination with IR.

Cell line	Time point (h)	Combination index (CI) TTFields+2 Gy	P-value	Combination index (CI) TTFields+4 Gy	P-value
H157	24	1.48	<0.0001	2.23	0.001
	48	2.08	<0.0001	1.14	0.003
	72	1.15	0.048	1.18	0.01
H4006	24	0.88	0.14	1.88	0.001
	48	1.01	<0.0001	1.74	0.003
	72	0.58	0.004	1.01	0.05
A549	24	1.88	<0.0001	1.50	0.12
	48	1.14	0.001	2.36	<0.0001
	72	0.86	0.14	1.99	0.0007
H1650	24	1.48	0.17	1.19	0.64
	48	1.21	<0.0001	0.90	0.21
	72	1.35	<0.0001	1.47	0.03
H1299	24	0.91	0.68	3.32	<0.0001
	48	0.79	0.09	3.97	<0.0001
	72	0.94	0.04	2.42	0.0003

Radiosensitization of TTFields was evaluated by the Highest Single Agent approach for combinations of 2 Gy+TTFields and 4 Gy+TTFields. Bold text denotes a statistically significant synergistic effect (CI>1 and P-value⩽0.05) for given time point post IR and a given cell line (N=3)