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. 2017 Mar 16;8(3):e2668. doi: 10.1038/cddis.2017.37

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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PrP^C modulates the RhoA-ROCK-LIMK-cofilin pathway. (a-c) Phosphorylation of RhoA, LIMK1/2, and cofilin in ZW and Zpl cells (a), in ZW cells transfected with scrambled RNA (SCR) or mPrP-targeted siRNA (Si-PrP) (b) and in Zpl cells with or without expressing mPrP (c) was analyzed in triplicate by western blot. The intensities of the bands in each panel were measured and quantified for each group, and the values are expressed as the mean±S.E. of three independent experiments (*P<0.05, **P<0.01, ***P<0.001, n=3)