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. 2017 Mar 2;8(3):e2642. doi: 10.1038/cddis.2017.5

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Drosha silence inhibits GC cell invasion. (a) The efficiency of short hairpin RNAs (shRNAs) against Drosha in 293T cells was determined by qRT-PCR (*P<0.05, **P<0.01 versus control shRNA). (b and c) Interference of Drosha in HGC-27, NUGC-3 and MGC-803 GC cells was detected by qRT-PCR (b) and western blotting (c) (**P<0.01 versus control shRNA). β-Actin works as a loading control. (d and e) Cell mobility and invasion were tested by wound healing assay (d) or Transwell assay (e) for indicated GC cells with specific shRNA (2# or 3#) against Drosha. The mobility ability was determined as the percentage of non-healed scratched area by using the Image J software. The data are presented as the mean±S.D. (n=3; **P<0.01 versus control shRNA)