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. 2017 Mar 23;8(3):e2697. doi: 10.1038/cddis.2017.91

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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BRE knockout mice produce smaller ovaries. (a) Representative appearance of 40-week-old BRE^+/+, BRE^+/− and BRE^−/− ovaries. (b and c) Plot charts comparing the ovarian volumes (b) and weights amongst the three groups of ovaries. (d–f) Representative immunofluorescent micrographs of BRE^+/+ (d), BRE^+/− (e) and BRE^−/− (f) ovarian sections stained with BRE antibodies. The staining confirms that BRE^−/− mutant primordial (f), primary (f1), secondary (f2) and antral (f3) follicles do not express BRE. Furthermore, in BRE^+/+ and BRE^+/− follicles, BRE is manly expressed in the granulosa cells (d and e). PdF, primordial follicle; PF, primary follicle; SF, secondary follicle; TC, theca cells; GC, granulosa cells. Scale bars=1000 μm in a; 50 μm in d2, e2 and f2; 50 μm in d3, e3, f3