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. 2017 Mar 23;8(3):e2697. doi: 10.1038/cddis.2017.91

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Ovarian sections immunofluorescently stained for PCNA and pHIS3. Representative micrographs of developing follicles stained for PCNA (a–f) and pHIS3 (i–n) to demonstrate the extent of granulosa cell proliferation in the follicles. (g and h) Bar charts comparing the average number of PCNA⁺ granulosa cells in antral follicles of 17- (g) and 40- (h) week-old BRE^+/+, BRE^+/− and BRE^−/− ovaries. (o and p) Bar charts comparing the average number of pHIS3⁺ granulosa cells in antral follicles. (q) Pie chart predicting where BRE targets the cell cycle during granulosa cell proliferation (as predicted from the BRE^−/− results). AF, antral follicle; GC, granulosa cells. Scale bar=100 μm in a–n