Table 2.
Comparison of cytogenetic profile between AML patients with and without CNS involvement at diagnosis or relapse
| Cytogenetic profile | AML patients at diagnosis n=3,261
|
p-Value | |
|---|---|---|---|
| Patients with CNS involvement at initial diagnosis and relapse n=55 | Patients without CNS involvement at any time n=3,206 | ||
| Normal karyotype, n (%) | 16 (31) | 1,472 (50) | 0.158 |
| Trisomy 8, n (%) | 10 (21) | 254 (8) | 0.001 |
| Trisomy 22, n (%) | 3 (6) | 62 (2) | 0.034 |
| Trisomy 11, n (%) | 1 (2) | 35 (1) | 0.514 |
| Trisomy 13, n (%) | 1 (2) | 42 (1) | 0.641 |
| Trisomy 21, n (%) | 2 (4) | 69 (2) | 0.343 |
| Monosomy 5, n (%) | 0 (0) | 26 (1) | 0.531 |
| Monosomy 7, n (%) | 0 (0) | 144 (4) | 0.133 |
| t(3;3), n (%) | 0 (0) | 8 (1) | 0.729 |
| t(1;7), n (%) | 0 (0) | 1 (0) | 0.903 |
| t(6;11), n (%) | 1 (2) | 6 (0) | 0.005 |
| t(8;21), n (%) | 2 (4) | 128 (4) | 0.951 |
| t(9;11), n (%) | 3 (6) | 41 (1) | 0.003 |
| t(6;9), n (%) | 0 (0) | 22 (1) | 0.565 |
| t(9;22), n (%) | 0 (0) | 7 (1) | 0.746 |
| t(11;19), n (%) | 0 (0) | 16 (1) | 0.624 |
| inv(16), n (%) | 3 (6) | 150 (5) | 0.610 |
| Inv(3) (q21q26) | 0 (0) | 20 (1) | 0.583 |
Abbreviations: AML, acute myeloid leukemia; CNS, central nervous system.