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. 2016 Nov 4;8(12):18773–18791. doi: 10.18632/oncotarget.13095

Figure 2.

Figure 2

(A–C) Cross species effects of pro-apoptotic miRNAs - initially identified in CHO [24] - in human tumor cell lines and pro-apoptotic effects of mouse miR-297-669 cluster. The revalidation screening was performed using the conditions described in Figure 1. To compare the effect of the transfected miRNAs (murine, mmu-miR-133a-5p, -96-5p, -185-5p, -551-3p) a non-targeting control (NT) was used (A). The transfected pro-apoptotic miRNA mimics of the 297-669 cluster (B) show a high degree of homology of the putative comparable possible seed sequences for the 3p and the 5p members (C). The sequence homology of the mature miRNAs was analyzed by CLUSTALW. Statistical analysis was performed by two-way ANOVA followed by Bonferroni post-test [n = 3; Mean ± SD, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001] #passenger strand (miRBase Version 21).