Figure 4. Molecular alterations induced by OCT4A overexpression in medulloblastoma cells.

(A) Differences in copy number profiles of the OCT4A overexpressed cells compared to their parental tumor cells. All chromosomes from 1p (left) to 22q, X and Y are represented. The blue bars above and below the middle lines (zero or no difference) represent more and less copy numbers, respectively. (B) Differences in copy number profiles of chromosomes 1 and 9 for OCT4A overexpressed medulloblastoma cell lines. Daoy, differences are highlighted in Green and USP-13-Med in Orange. (C) Cluster analysis of commonly differentiated expressed genes due to OCT4A overexpression. D: Daoy Control; DM: D283Med Control; U: USP-13-Med Control; D Oct: Daoy overexpressing OCT4A; DM Oct: D283Med overexpressing OCT4A; U Oct: USP-13-Med overexpressing OCT4A. Data are presented as average normalized signal in Log₂. Genes were functionally classified according to Ensembl definition. (D) Chromosomal location of commonly differentiated expressed genes after OCT4A overexpression in Daoy, D283Med and USP-13-Med cells.