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. 2017 Feb 7;8(12):19218–19235. doi: 10.18632/oncotarget.15168

Figure 6. Alterations of FAM84B expression in animal models of castration resistant PC.

Figure 6

(A) PSA levels in NOD/SCID mice (n = 3) bearing LNCaP cell-derived xenograft tumors prior to and after castration; a typical pattern from a single mouse is shown. (B) Real time PCR analysis of FAM84B mRNA in hormone sensitive (HS) and castration resistant PC (LNCaP xenograft tumors). *p < 0.05 by a 2-tailed Student's t-test in comparison to hormone naive xenograft tumors. HS PC: hormone sensitive prostate cancer. (C) IHC staining of FAM84B in prostate tumors produced in intact and castrated PTEN−/− mice (n = 3; see Supplementary Figure 7 for the production of prostate specific PTEN−/− mice). Indicated regions are enlarged 2.5 fold and placed beneath the original panel.