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. 2017 Feb 8;8(12):19285–19297. doi: 10.18632/oncotarget.15195

Figure 7. Schematic model of the feedback circuitry between c-Myc and CCAT1 acting via let-7c in CSE-induced transformation of HBE cells.

Figure 7

In HBE cells, CSE induces increases of CCAT1 levels and binding of let-7c and decreases of free let-7c levels, which causes increases of c-Myc. The enhancement of c-Myc promotes the expression of CCAT1 via binding to the promoter of CCAT1. The feedback circuitry, via let-7c between c-Myc and CCAT1, is involved in CSE-induced malignant transformation of HBE cells.