Table 2. Genetic variants in the RhoA/ROCK1 pathway associated with the PCa risk.
| Genetic Variants | Case (n = 830) | Control (n = 869) | Pa | Adjusted OR (95% CI)b | ||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| RhoA rs2410 | ||||||
| AA | 199 | 24.0 | 233 | 26.8 | 0.059 | 1.00 (reference) |
| AC | 378 | 45.5 | 415 | 47.8 | 0.591 | 1.06 (0.84–1.35) |
| CC | 253 | 30.5 | 221 | 25.4 | 0.028 | 1.11 (1.01–1.21) |
| AC+CC | 631 | 76.0 | 636 | 73.2 | 0.180 | 1.11 (1.02–1.21) |
| A allele | 776 | 46.8 | 881 | 50.7 | 0.022 | 1.00 (reference) |
| C allele | 884 | 53.2 | 857 | 49.3 | 1.18 (1.03–1.35) | |
| RhoA rs2625955 | ||||||
| AA | 325 | 39.2 | 348 | 40.1 | 0.849 | 1.00 (reference) |
| AC | 376 | 45.3 | 394 | 45.3 | 0.938 | 0.99 (0.80–1.22) |
| CC | 129 | 15.5 | 127 | 14.6 | 0.567 | 1.01 (0.92–1.12) |
| AC+CC | 505 | 60.8 | 521 | 59.9 | 0.708 | 1.01 (0.92–1.12) |
| A allele | 1026 | 61.8 | 1090 | 62.7 | 0.585 | 1.00 (reference) |
| C allele | 634 | 38.2 | 648 | 37.2 | 1.01 (0.88–1.17) | |
| RhoA rs2269736 | ||||||
| AA | 186 | 22.4 | 116 | 13.3 | < 0.001 | 1.00 (reference) |
| AG | 399 | 48.1 | 404 | 46.5 | < 0.001 | 0.63 (0.48–0.82) |
| GG | 245 | 29.5 | 349 | 40.2 | < 0.001 | 0.76 (0.69–0.83) |
| AG+GG | 644 | 77.6 | 753 | 86.7 | < 0.001 | 0.79 (0.72–0.86) |
| A allele | 771 | 46.5 | 636 | 36.6 | < 0.001 | 1.00 (reference) |
| G allele | 889 | 53.5 | 1102 | 63.4 | 0.66 (0.57–0.76) | |
| ROCK1 rs11874761 | ||||||
| AA | 12 | 1.4 | 11 | 1.3 | 0.914 | 1.00 (reference) |
| AG | 169 | 20.4 | 182 | 20.9 | 0.708 | 0.80 (0.34–1.90) |
| GG | 649 | 78.2 | 676 | 77.8 | 0.761 | 0.93 (0.71–1.23) |
| AG+GG | 818 | 98.6 | 858 | 98.7 | 0.748 | 0.99 (0.88–1.11) |
| A allele | 193 | 11.6 | 204 | 11.7 | 0.920 | 1.00 (reference) |
| G allele | 1467 | 88.4 | 1534 | 88.3 | 0.97 (0.79–1.20) | |
| ROCK1 rs35996865 | ||||||
| GG | 16 | 1.9 | 15 | 1.8 | 0.140 | 1.00 (reference) |
| GT | 179 | 21.6 | 155 | 17.8 | 0.833 | 1.03 (0.48–2.18) |
| TT | 635 | 76.5 | 699 | 80.4 | 0.658 | 0.94 (0.74–1.20) |
| GT+TT | 814 | 98.1 | 854 | 98.2 | 0.756 | 0.89 (0.80–0.99) |
| G allele | 211 | 12.7 | 185 | 10.6 | 0.061 | 1.00 (reference) |
| T allele | 1449 | 87.3 | 1553 | 89.4 | 0.80 (0.65–0.99) | |
| ROCK1 rs8089974 | ||||||
| GG | 8 | 1.0 | 14 | 1.6 | 0.119 | 1.00 (reference) |
| GT | 174 | 20.9 | 153 | 17.6 | 0.126 | 2.01 (0.80–5.08) |
| TT | 648 | 78.1 | 702 | 80.8 | 0.278 | 1.16 (0.86–1.56) |
| GT+TT | 822 | 99.0 | 855 | 98.4 | 0.238 | 0.93 (0.83–1.04) |
| G allele | 190 | 11.5 | 181 | 10.4 | 0.335 | 1.00 (reference) |
| T allele | 1470 | 88.5 | 1557 | 89.6 | 0.89 (0.71–1.10) | |
Bold values indicated significant differences between two groups.
aTwo-sided χ2 test for either genotype distributions or allele frequencies between the cases and controls. All P values were Bonferroni corrected, and statistical significance was set at P < 0.01667 (0.05/3).
bAdjusted for age, bmi, pack-years of smoking, drinking status, tea drinking, hypertension and diabetes in logistic regression model.