Table 3. Comparison of incidence and hazard ratio of AMI between patients with and without ADPKD, stratified by gender, age and comorbidities.
| Variables | ADPKD | IRR (95% CI) | Adjusted HR (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|
| No (N = 20620) | Yes (N = 2062) | |||||||
| Event | PY | Rate | Event | PY | Rate | |||
| Acute myocardial infarction | 201 | 138508 | 145.1 | 60 | 13059 | 459.5 | 3.17 (2.37 - 4.22)*** | 2.43 (1.8 - 3.29)*** |
| Sex | ||||||||
| Female | 67 | 72435 | 92.5 | 21 | 6923 | 303.3 | 3.28 (2.01 - 5.35)*** | 2.7 (1.62 - 4.47)*** |
| Male | 134 | 66073 | 202.8 | 39 | 6136 | 635.6 | 3.13 (2.19 - 4.48)*** | 2.3 (1.58 - 3.35)*** |
| Age | ||||||||
| 18-39 | 9 | 38312 | 23.5 | 2 | 3788 | 52.8 | 2.25 (0.49 - 10.4) | 1.22 (0.19 - 8.03) |
| 40-65 | 114 | 85756 | 132.9 | 45 | 8125 | 553.8 | 4.17 (2.95 - 5.88)*** | 2.74 (1.91 - 3.94)*** |
| >65 | 78 | 14440 | 540.2 | 13 | 1146 | 1134.4 | 2.1 (1.17 - 3.78)* | 1.95 (1.08 - 3.51)* |
| Comorbidities | ||||||||
| Hypertension | ||||||||
| No | 41 | 91966 | 44.6 | 5 | 2129 | 234.9 | 5.27 (2.08 - 13.33)*** | 6.49 (2.52 - 16.7)*** |
| Yes | 160 | 46542 | 343.8 | 55 | 10930 | 503.2 | 1.46 (1.08 - 1.99)* | 2.21 (1.61 - 3.03)*** |
| Diabetes mellitus | ||||||||
| No | 113 | 116325 | 97.1 | 45 | 11138 | 404 | 4.16 (2.94 - 5.88)*** | 2.64 (1.83 - 3.83)*** |
| Yes | 88 | 22183 | 396.7 | 15 | 1921 | 780.8 | 1.97 (1.14 - 3.4)* | 2.05 (1.18 - 3.56)* |
| Dyslipidemia | ||||||||
| No | 114 | 106456 | 107.1 | 33 | 8513 | 387.6 | 3.62 (2.46 - 5.33)*** | 2.49 (1.66 - 3.74)*** |
| Yes | 87 | 32052 | 271.4 | 27 | 4546 | 593.9 | 2.19 (1.42 - 3.37)*** | 2.29 (1.46 - 3.59)*** |
| Atrial fibrillation | ||||||||
| No | 181 | 136277 | 132.8 | 55 | 12713 | 432.6 | 3.26 (2.41 - 4.4)*** | 2.54 (1.85 - 3.49)*** |
| Yes | 20 | 2231 | 896.5 | 5 | 346 | 1445.1 | 1.61 (0.61 - 4.3) | 1.57 (0.56 - 4.39) |
| Ischemic heart disease | ||||||||
| No | 0 | 115228 | 0 | 0 | 9556 | 0 | ---† | --- |
| Yes | 201 | 23280 | 863.4 | 60 | 3503 | 1712.8 | 1.98 (1.49 - 2.65)*** | 2.17 (1.61 - 2.93)*** |
| Heart failure | ||||||||
| No | 142 | 132487 | 107.2 | 41 | 11639 | 352.3 | 3.29 (2.32 - 4.65)*** | 2.57 (1.78 - 3.71)*** |
| Yes | 59 | 6021 | 979.9 | 19 | 1420 | 1338 | 1.37 (0.81 - 2.29) | 1.49 (0.86 - 2.56) |
| Peripheral vascular disease | ||||||||
| No | 185 | 133663 | 138.4 | 54 | 12072 | 447.3 | 3.23 (2.39 - 4.38)*** | 2.42 (1.76 - 3.33)*** |
| Yes | 16 | 4845 | 330.2 | 6 | 987 | 607.9 | 1.84 (0.72 - 4.7) | 2.65 (0.96 - 7.25) |
| Chronic kidney disease | ||||||||
| No | 178 | 135392 | 131.5 | 21 | 6159 | 341 | 2.59 (1.65 - 4.08)*** | 2.82 (1.76 - 4.53)*** |
| Yes | 23 | 3116 | 738.1 | 39 | 6900 | 565.2 | 0.77 (0.46 - 1.28) | 1.14 (0.65 - 2) |
| Malignancy of kidney or bladder | ||||||||
| No | 196 | 137883 | 142.1 | 59 | 12620 | 467.5 | 3.29 (2.46 - 4.4)*** | 2.55 (1.88 - 3.47)*** |
| Yes | 5 | 625 | 800 | 1 | 439 | 227.8 | 0.28 (0.03 - 2.44) | --- |
* p<0.05, **p<0.01, ***p<0.001
†Insufficient case number for statistical analysis
Rate denotes incidence rate (per 100,000).
Adjusted HR (hazard ratio) indicates multivariate analysis with adjusting for age, gender, and comorbidities.
AMI = acute myocardial infarction, ADPKD = autosomal dominant polycystic kidney disease,
PY = person-year, IRR = incidence rate ratio, CI = confidence interval.