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. 2016 Dec 27;8(12):19413–19426. doi: 10.18632/oncotarget.14297

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Copyright: © 2017 Liu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Both diabetes-induced chronic hyperglycemia and acute hyperglycemia increased ALDH2 O-GlcNAc modification which decreased its activity, toxical aldehydes accumulation and cell apoptosis, thus contributing to the exacerbation of myocardial ischemia/reperfusion injury. Alda-1 reversed myocardial ischemia/reperfusion injury exacerbated by hyperglycemia through decreasing ALDH2 O-GlcNAc modification, as well as increasing its activity.