Table 5. Receiver operating characteristic (ROC) curve for various cutoff levels of PON1 in the differentiation of patients with CAD from non-CAD.
| PON1 activity (U/L) | Sensitivity (95%CI) | Specificity (95%CI) | DOC |
|---|---|---|---|
| 309 | 0.49 (0.44-0.53) | 0.73 (0.69-0.77) | 0.58 |
| 311 | 0.50 (0.45-0.54) | 0.70 (0.65-0.74) | 0.58 |
| 330 | 0.52 (0.48-0.56) | 0.65 (0.61-0.70) | 0.59(cutoff) |
| 348 | 0.55 (0.50-0.59) | 0.60 (0.56-0.65) | 0.60 |
| 366 | 0.62 (0.57-0.66) | 0.52 (0.48-0.57) | 0.61 |
* AUC: 0.600 (95% CI: 0.515 – 0.686), P =0.026
PON1, serum paraoxonase1; DOC, Distance on curve equaling square root of (1-Sen) 2+ (1-Spe) 2; AUC, Area under curve