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. 2017 Jan 19;8(12):19592–19608. doi: 10.18632/oncotarget.14752

Figure 1. miRs -21, -143, and -378 are co-expressed, miR-378 correlates with prognosis, and miR-143 correlates with tumor stages in breast cancer.

Figure 1

miR expression was evaluated using 744 Breast Invasive Carcinoma patients from TCGA database. Statistically significant co-expression of miRs -143 and -378 levels, and of miRs -143 and -21 levels were identified in the analyzed cohort. Statistical significance calculated using Pearson's correlation analysis. P<0.05 was considered significant a. Kaplan-Meier survival curve: correlation between miR-378 and overall survival of 20 highly and 44 poorly miR-378-expressing breast cancer patients in TCGA database. Low miR-378 expression predicted a better prognosis in the cohort. The patients were assigned to the high or low miR-378-expressing group using the media as a threshold. P-value calculated using Log-Rank test. P<0.05 was considered significant b. A significant increase in miR-143 expression was identified in high (III/IV) compared to low (I/II) breast cancer stages. Statistical significance calculated using Student's t-test. P<0.05 was considered significant c.