Figure 4. Representative mid-band fit data from other chromatin-altering treatments.

A. Results from DNase I, colchicine and cisplatinum treatments, indicating that conditions inducing chromatin condensation were sufficient to increase midband fit. A significant difference was determined to exist between colchicine and cisplatinum treatment. B. Results from isolated nuclei experiments involving cisplatinum treatment. Both isolated nuclei and whole cells demonstrated increased midband fit values after exposure to cisplatinum. Untreated control nuclei demonstrated a significantly higher midband fit value than untreated whole cells. *** indicates p<0.001 between the indicated condition and the corresponding untreated control. † indicates p<0.05 significance between colchicine and cisplatinum treatments. ## indicates p<0.01 significance between untreated nuclei and untreated whole cells. n ≥ 4 for all conditions.