Figure 6.

Fluorescence endomicroscopy images of tumor blood vessels from (A) a partial responder during a time of tumor regrowth at 3.5 weeks after reaching the experiment size of 8 mm, (B) a drug-only control at 2 weeks after reaching 8 mm and (C) an untreated control mouse at 1.5 weeks after reaching 8 mm. The “tortuous” blood vessel architecture seen in these images may explain the decrease in rBF in drug-only and untreated control tumors observed at 1 and 2 weeks when the tumors grew larger (Figures 4 and 5).