Table 2. Univariate and multivariate analyses for disease-free survival according to PLCB4 gene status, PLCß4 expression status, NCCN guidelines, and other prognostic factors.
| Parameter | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| No. Case | No. Event | p-value | HR | 95% CI | p-value | |
| Sex | 0.4667 | |||||
| Male | 177 | 43 | ||||
| Female | 173 | 44 | ||||
| Age (years) | 0.0584 | |||||
| <70 | 259 | 59 | ||||
| >=70 | 91 | 28 | ||||
| Location | 0.0023* | 0.385 | ||||
| Gastric | 211 | 40 | 1 | - | ||
| Non-gastric | 139 | 47 | 0.798 | 0.480-1.328 | ||
| Histologic Type | <0.0001* | 0.001* | ||||
| Spindle | 266 | 51 | 1 | - | ||
| Mixed/Epithelioid | 84 | 36 | 2.364 | 1.408-3.971 | ||
| Tumour Size (cm)# | <0.0001* | |||||
| =<5 cm | 161 | 16 | ||||
| >5; =<10 cm | 131 | 38 | ||||
| >10 cm | 58 | 33 | ||||
| Mitotic Count (50HPFs)# | <0.0001* | |||||
| 0-5 | 249 | 33 | ||||
| 6-10 | 43 | 14 | ||||
| >10 | 58 | 40 | ||||
| NCCN Guideline | <0.0001* | <0.001* | ||||
| None/Very low | 88 | 3 | 1 | - | ||
| Low | 100 | 10 | 2.461 | 0.519-11.675 | ||
| Moderate | 65 | 15 | 2.566 | 0.541-12.173 | ||
| High | 97 | 59 | 8.408 | 1.913-36.963 | ||
| Mutation Type | 0.0005* | 0.091 | ||||
| Favorable type | 106 | 22 | 1 | - | ||
| Unfavorable type | 107 | 45 | 1.584 | 0.929-2.701 | ||
| PLCß4 expression | <0.0001* | 0.007* | ||||
| Low Expressed | 175 | 20 | 1 | - | ||
| High Expression | 175 | 67 | 2.454 | 1.274-4.730 | ||
| PLCB4 gene status | <0.0001* | 0.031* | ||||
| No gain | 245 | 31 | 1 | - | ||
| Polysomy & Amp. | 105 | 56 | 1.892 | 1.062-3.370 | ||
#, Tumour size and mitotic activity were not introduced in multivariate analysis, since these two parameters were component factors of NCCN risk scheme; *, Statistically significant. HR, hazard ratio.