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. 2017 Feb 16;8(12):20067–20085. doi: 10.18632/oncotarget.15379

Figure 1. Apoptosis inducing SFF-CD95L activates the A-SMase in SKW6.4 cell lysates in a biphasic manner.

Figure 1

a. Induction of apoptosis in SKW6.4 cells after treatment with 100 ng/ml SFF-CD95L analyzed by AnnexinV/propidium iodide staining. b. Western blot analysis of SFF-CD95L induced activation of caspases. Initiator caspase-8 as well as effector caspases-3 or -7 showed a type I cell line dependent activation kinetic. c. Time course of A-SMase activity determined in SKW6.4 cell lysates after SFF-CD95L treatment. The activity maximums appeared after 15 and 90 minutes SFF- CD95L stimulation (n=3, 1way-Anova with Bonferroni's multiple comparison test).