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. 2017 Feb 16;8(12):20067–20085. doi: 10.18632/oncotarget.15379

Figure 2. The SFF-CD95L induces the CD95-internalization in type I cells.

Figure 2

a. Immunofluorescence analysis of SFF-CD95L induced CD95 internalization in HuT78 cells. The CD95L induced a time-dependent internalization of the CD95 receptor which is blocked by the dynamin-specific inhibitor Dynasore. b. Time course of intracellular CD95-receptosome trafficking (left panel) and corresponding non-magnetic fractions (right panel) in SKW6.4 cells. Magnetic and non-magnetic fractions derived after indicated times of CD95 internalization were analyzed for CD95, DISC proteins (FADD and Caspase-8), clathrin (Clathrin HC), early endosomes (Rab 4A) and lysosomes (Cathepsin D).