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. 2016 Nov 3;8(12):20340–20353. doi: 10.18632/oncotarget.13050

Figure 4. Radionecrosis in a 45-year-old woman with anaplastic astrocytoma in the right parietooccipital lobe who underwent gross total resection and concomitant chemoradiotherapy (CCRT).

Figure 4

a. Contrast-enhanced T1-weighted (CET1) magnetic resonance (MR) image obtained 18 months after CCRT completion shows newly appearing multifocal enhancing lesions in the right occipital lobe (arrow). b. Susceptibility-weighted imaging demonstrates significant dark areas in the corresponding enhancing lesions (arrow); the proportion of dark signal intensity (proSWMRI) was 62.95 %. c. The normalized relative cerebral blood volume map (nCBV) from dynamic susceptibility contrast perfusion-weighted imaging shows increased blood flow in the corresponding enhancing area (arrow) (calculated 90th percentile points in the cumulative nCBV histogram (nCBV90) = 2.88). d. Hematoxylin-eosin-stained histopathology (original magnification, X 10) shows multiple hemorrhages of > 5 mm (arrows) within the radionecrosis.