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. 2016 Nov 3;8(12):20340–20353. doi: 10.18632/oncotarget.13050

Figure 3. Recurrence in a 58-year-old woman with anaplastic astrocytoma in the left parietal lobe who underwent gross total resection and concomitant chemoradiotherapy (CCRT) with temozolomide.

Figure 3

a. Contrast-enhanced T1-weighted (CET1) magnetic resonance (MR) image obtained 14 months after CCRT completion shows a newly appearing enhancing lesion in the left parietal lobe (arrow). b. Susceptibility-weighted imaging demonstrates nearly no dark area in the corresponding lesion (arrow); the proportion of dark signal intensity was 0.30 %. c. The normalized relative cerebral blood volume map (nCBV) from dynamic susceptibility contrast perfusion-weighted imaging shows increased blood flow in the corresponding enhancing area (arrow) (calculated 90th percentile points in the cumulative nCBV histogram (nCBV90) = 5.13). d. Hematoxylin-eosin-stained histopathology (original magnification, X 10) shows multiple hemorrhages of ≤ 5 mm (arrows) within the recurrent anaplastic astrocytoma.