Skip to main content
. 2016 Nov 3;8(12):20340–20353. doi: 10.18632/oncotarget.13050

Figure 6. Flow chart of quantitative image analysis.

Figure 6

Region of interest (ROI) was manually selected in each section of the enhancing lesions and was semi-automatically co-registered with the normalized relative cerebral blood volume map (nCBV) and susceptibility-weighted magnetic resonance imaging sequences (SWMRI) map. The volume of interest was determined by the summation of each slice; nCBV values and SWMRI values for the entire enhancing lesion were obtained. Cumulative histogram analysis was performed for whole nCBV values. In the cumulative nCBV histograms, mean nCBV, and the 70th, 90th, 95th and 99th percentile points (nCBV70, nCBV90, nCBV95 and nCBV99, respectively) were derived. For SWMRI values, by setting the median SWMRI SI of the ventricular system as the reference, the proportion of SWMRI (proSWMRI) was calculated by dividing the number of pixels below the reference SWMRI SI by the total number of pixels. Note: ROI = region of interest, SWMRI = susceptibility-weighted magnetic resonance imaging sequences, SI = signal intensity, CBV = cerebral blood volume, the Xth percentile point = point at which X% of the voxel values that form the histogram are found to the left of the histogram.