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. 2017 Jan 18;8(12):20462–20475. doi: 10.18632/oncotarget.14726

Figure 3. The action mechanisms of lncRNAs in OS chemoresistance.

Figure 3

A. Cisplatin induces expression of LINC00161, which sponges miR645 to reverse drug resistance. B. HOTTIP contributes to drug resistance through activating Wnt/β-catenin signaling. C. ORDUL increases drug resistance by elevating ABCB1. D. High expression of FOXC2-AS1 causes drug resistance with increased ABCB1 and HIF1A. (The solid arrow represents promoting and the dashed arrow represents inhibiting.)