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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Neuropharmacology. 2017 Feb 3;117:158–170. doi: 10.1016/j.neuropharm.2017.02.001

Figure 1.

Figure 1

Evaluation of anxiety-like baseline behaviors in stress naïve TH-Rictor-KO mice. There were no statistical differences in anxiety-like behaviors including time spent in the open arms of the EPM test (A: male: CON=6, HET=10, KO=10; female: CON=15, KO=11) or center time in the OF test (B: male: CON=18, HET=36, KO=22; female: CON=20, KO=12) between control, heterozygous, or homozygous male (left) or female (right) TH-Rictor-KO mice. Homozygous male TH-Rictor-KO mice exhibited increased locomotor activity in the OF test compared to controls (CON=19, HET=36, KO=23), but this difference was not observed in female Rictor-KO-mice (CON=28, KO=15) (C), *p<0.05, n=6–36 mice/group, individual data points shown.