FIG. 4.

Space-filled representation of the proposed functionally important class-specific residues for the P06 partitions of the phylogenetic tree. The buried atoms of the class-specific residues are shown in blue and the exposed atoms of these residues are cyan. (A) The S domain surface patches 1 to 5 are outlined in black. The red box indicates that the S domain surface patches 2 and 4 may be considered as one single such patch. (B) The different class-specific surface patches CS-2, CS-4, and CS-5 of Table 4 are outlined in red. The surface CS-1 is outlined in black. Another possible class-specific surface consisting of the residues A402 and S447 lies near the CS-1surface. The red outline enclosing the two class-specific patches outlined in black indicates that these patches may be considered as a single patch. The purple outline enclosing the S domain patch number 1 and the P domain CS-1 patch indicates that these patches may be considered as one single patch or a pair of possible neutralizing and nonneutralizing epitope sites. The direction of the icosahedral twofold axis relative to the capsid subunit is also shown. (C) A 180° rotated view of the figure in panel B. This figure indicates the surface patch CS-3 that is not visible in panel B. The surface patch CS-2 is also shown to indicate the relative location of the CS-3 patch.