TABLE 3.
Surface-forming neighbors of class-specific residues that distinguish the GI noroviruses from the GII strains in partitions P02 to P04
| Class-specific residues (NV numbering) | Surface | Neighbors forming the surfacesa |
|---|---|---|
| 1044A# | 1 | 1042A, 1043V*, 1045T*#, 1046A |
| 1070I | 2 | 1069T, 1071S, 1202V$%, 1074N, 1186L, 1080L, 1113L$, 1152V, 1190L%, 1201V$ |
| 1104V, 1106N | 3 | 1036V#, 1037A*#, 1103W, 1105G, 1106N, 1107M, 1108R, 1162L, 1163E, 1164D, 1166R, 1169L*, 1170F, 1213D, 1214F, 1215N, 1217L |
| 1163E | 4 | 1033M*#$, 1034D*, 1036V, 1106N, 1162L, 1164D, 1165V*#, 1180M |
| 1201V$%, 1203A*, 1204G | 5 | 1067E$, 1068F$, 1070I, 1071S, 1112M*$, 1113L$, 1114A*$, 1200F$%, 1202V$, 1203A*$, 1205R*$%, 1512Q |
| 1226Q | 6 | 1225E*#, 1227K*, 1229R, 1449Q*, 1228T |
| 1329H§, 1375W§, 1377S | 7 | 1326C, 1327D, 1328W, 1330I§, 1342Q§, 1343Y, 1344D, 1374S, 1376I, 1378P, 1379P, 1426P§, 1427G§, 1428P§, 2338S, 2339S, 2340Q |
| 1397S* | 8 | 1353V, 1395Y, 1396G, 1398S, 1399I* |
| 1414F | 9 | 1074N, 1412P, 1413G, 1415G*, 1484V, 1512Q |
| 1434P | 10 | 1245R, 1265F, 1389L, 1390W, 1420F, 1421F, 1422M, 1432N*, 1433L, 1435C |
| 1460H, 1463D, 1500V | 11 | 1235N*, 1236L, 1459L, 1461Y, 1462V, 1464P*$%, 1465D$%, 1466T$%, 1467G$%, 1468R*%, 1469N*, 1471G, 1472E, 1499G, 1501F, 1502V$, 1504V |
| 1471G | 13 | 1461Y, 1470L, 1472E, 1516V, 1518T, 1519A |
| 1485P, 1486N | 14 | 1417V, 1483C, 1484V, 1487G, 1488A*, 1490S, 1516V, 1517G, 1518T, 1519A |
| 1514K*$% | 15 | 1484V, 1513L, 1515P*, 1516V |
These 4.0 Å sphere neighbors form class-specific surfaces (in boldface) in the NV crystal structure. The C terminus residues are italicized. To identify the different subunits, residues are denoted as xxxxN where xxxx is a four-digit number and N is the single-letter amino acid code of the residue. The first digit of xxxx refers to the subunit number (1, A; 2, B; 3, C) and the remaining three digits are the residue numbers; e.g., residue 1044 refers to 44 of A subunit; residue 2338 refers to residue 338 of B subunit. Superscript asterisk denotes exposed residues. The symbol # denotes residues interacting across the quasi-three fold axis, while the symbols §, $, and % denote residues interacting across the icosahedral twofold, fivefold, and threefold axes respectively.