Table 3.

Baseline characteristics associated with death by 12 months among children with Burkitt lymphoma in Lilongwe, Malawi.

Variable	Unadjusted hazard ratio	95% CI	P value	Adjusted hazard ratio	95% CI	P value
Entire cohort (n=88)
Baseline pEBV DNA, per log10copies/mL	1.19	1.03–1.37	0.019	1.05	0.91–1.22	0.50
Female gender	1.65	0.93–2.91	0.085	1.39	0.76–2.54	0.28
Age ≥9 years	2.24	1.22–4.13	0.009	1.89	0.98–3.63	0.056
Stage III/IV	2.23	1.00–4.97	0.049	1.32	0.56–3.13	0.52
Lansky performance status <70	2.80	1.31–5.98	0.008	2.38	1.02–5.59	0.046
Lactate dehydrogenase, per 100 IU/L	1.03	1.01–1.04	<0.001	1.02	1.00–1.03	0.015
Underweight statusA	1.74	0.99–3.05	0.056	1.33	0.72–2.44	0.36
Baseline pEBV+ only (n=76)
Baseline pEBV DNA, per log10copies/mL	1.64	1.27–2.12	<0.001	1.35	1.04–1.75	0.023
Female gender	1.89	1.03–3.48	0.041	1.49	0.78–2.85	0.23
Age ≥9 years	2.47	1.28–4.76	0.007	1.49	0.73–3.05	0.27
Stage III/IV	2.54	1.00–6.46	0.051	1.37	0.48–3.94	0.56
Lansky performance status <70	2.94	1.15–7.48	0.024	2.29	0.81–6.47	0.12
Lactate dehydrogenase, per 100 IU/L	1.03	1.01–1.04	<0.001	1.01	1.00–1.03	0.13
Underweight statusA	2.24	1.22–4.13	0.010	1.63	0.84–3.15	0.15

CI = confidence interval. pEBV = plasma Epstein-Barr virus.

^AUnderweight was defined as weight-for-age z-score <−2 if <5 years or body mass index (BMI) z-score <−2 if ≥5 years.