Table 1. ASD outcome association with organohalogens in mothers after adjustment for sociodemographic covariates and for maternal and fetal ancestry.
| Maternal Ancestry-Adjusted | Fetal Ancestry-Adjusted | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Compound | N | β | SE | OR (95% CI) | P-Valuea | N | β | SE | OR (95% CI) | P-Valuea |
| Persistent pesticides | ||||||||||
| p-p′-DDE | 762 | −0.08 | 0.06 | 0.92 (0.82–1.04) | NS | 708 | −0.08 | 0.07 | 0.92 (0.80–1.06) | NS |
| T-NONA | 706 | 0.01 | 0.04 | 1.01 (0.94–1.09) | NS | 656 | −0.01 | 0.04 | 0.99 (0.92–1.07) | NS |
| Polybrominated diphenyl ethers and biphenyls | ||||||||||
| BB-153 | 705 | −0.01 | 0.05 | 0.99 (0.90–1.09) | NS | 655 | −0.02 | 0.05 | 0.98 (0.89–1.08) | NS |
| BDE-28 | 698 | −0.03 | 0.05 | 0.97 (0.88–1.07) | NS | 649 | −0.02 | 0.05 | 0.98 (0.89–1.08) | NS |
| BDE-47 | 762 | −0.14 | 0.08 | 0.87 (0.74–1.02) | 0.07 | 708 | −0.13 | 0.08 | 0.88 (0.75–1.03) | NS |
| BDE-99 | 741 | −0.13 | 0.07 | 0.88 (0.77–1.01) | 0.07 | 688 | −0.13 | 0.08 | 0.88 (0.75–1.03) | 0.09 |
| BDE-100 | 750 | −0.18 | 0.08 | 0.84 (0.71–0.98) | 1.97 × 10−2 | 697 | −0.2 | 0.08 | 0.82 (0.70–0.96) | 1.4 × 10−2 |
| BDE-153 | 749 | −0.2 | 0.07 | 0.82 (0.71–0.94) | 6.54 × 10−3 | 695 | −0.22 | 0.08 | 0.82 (0.69–0.94) | 4.1 × 10−3 |
| Sum PBDE | 710 | −0.16 | 0.07 | 0.85 (0.74–0.98) | 1.74 × 10−2 | 659 | −0.18 | 0.07 | 0.84 (0.73–0.96) | 1.1 × 10−2 |
| Polychlorinated biphenyls | ||||||||||
| PCB28 | 763 | 0.13 | 0.09 | 1.39 (0.96–1.26) | NS | 709 | 0.12 | 0.09 | 1.1 (0.95–1.35) | NS |
| PCB99 | 712 | −0.01 | 0.04 | 0.99 (0.92–1.07) | NS | 662 | −0.02 | 0.04 | 0.98 (0.91–1.06) | NS |
| PCB118 | 714 | 0.01 | 0.04 | 0.99 (0.92–1.07) | NS | 664 | −0.01 | 0.04 | 0.99 (0.92–1.07) | NS |
| PCB153 | 755 | 0.01 | 0.04 | 0.99 (0.92–1.07) | NS | 703 | −0.01 | 0.04 | 0.99 (0.92–1.07) | NS |
| PCB170 | 727 | −0.01 | 0.04 | 0.99 (0.92–1.07) | NS | 675 | −0.03 | 0.04 | 0.97 (0.90–1.05) | NS |
| PCB180 | 759 | 0.01 | 0.04 | 0.99 (0.92–1.07) | NS | 705 | −0.01 | 0.04 | 0.99 (0.92–1.07) | NS |
| PCB187 | 714 | −0.01 | 0.04 | 0.99 (0.92–1.07) | NS | 664 | −0.02 | 0.05 | 0.98 (0.89–1.08) | NS |
| PCB194 | 712 | −0.02 | 0.04 | 0.98 (0.91–1.06) | NS | 662 | −0.03 | 0.04 | 0.97 (0.89–1.05) | NS |
| PCB199 | 715 | −0.02 | 0.05 | 0.97 (0.89–1.05) | NS | 665 | −0.03 | 0.05 | 0.97 (0.88–1.07) | NS |
| PCB138/158 | 752 | 0.01 | 0.04 | 0.99 (0.92–1.07) | NS | 698 | −0.01 | 0.05 | 0.99 (0.90–1.09) | NS |
| PCB196/203 | 715 | −0.05 | 0.04 | 0.95 (0.88–1.03) | NS | 665 | −0.04 | 0.04 | 0.97 (0.89–1.04) | NS |
| Sum PCB | 706 | 0.03 | 0.05 | 1.03 (0.93–1.13) | NS | 657 | 0.01 | 0.05 | 1.01 (0.92–1.11) | NS |
SE, standard error; OR, odds ratio; CI 95%, confidence interval 95%.
a
Significance of ASD outcome in each congener linear regression model.