Table 2. SNP-based maternal and fetal heritability for polybrominated diphenyl ethers (PBDEs) and 2,2′,4,4′,5,5′-hexabromobiphenyl (BB-153) in maternal serum.
Maternal Genetics | Fetal Genetics | |||||
---|---|---|---|---|---|---|
Compound | h2g | SE | P-Value | h2g | SE | P-Value |
Persistent pesticides | ||||||
p,p′-DDE | 0 | 0.32 | NS | 0 | 0.36 | NS |
T-NONA | 0 | 0.35 | NS | 0 | 0.37 | NS |
Polybrominated diphenyl ethers and biphenyls | ||||||
BB-153 | 0.93 | 0.31 | 4.5 × 10−3 | 0.98 | 0.33 | 4.0 × 10−3 |
BDE-28 | 0.53 | 0.33 | NS | 0.82 | 0.34 | 1.3 × 10−2 |
BDE-47 | 0.73 | 0.31 | 1.6 × 10−2 | 0.99 | 0.31 | 1.6 × 10−3 |
BDE-99 | 0.39 | 0.33 | NS | 0.66 | 0.34 | 2.3 × 10−2 |
BDE-100 | 0.93 | 0.29 | 1.7 × 10−3 | 0.99 | 0.32 | 7.2 × 10−5 |
BDE-153 | 0.79 | 0.3 | 5.4 × 10−3 | 0.99 | 0.31 | 4.7 × 10−4 |
Sum PBDE | 0.77 | 0.31 | 8.3 × 10−3 | 0.91 | 0.33 | 5.2 × 10−3 |
Polychlorinated biphenyls | ||||||
PCB28 | 0 | 0.32 | NS | 0 | 0.36 | NS |
PCB99 | 0 | 0.35 | NS | 0.06 | 0.37 | NS |
PCB118 | 0.07 | 0.34 | NS | 0 | 0.38 | NS |
PCB153 | 0.36 | 0.32 | NS | 0.58 | 0.34 | 4.54 × 10−2 |
PCB170 | 0.39 | 0.33 | NS | 0.37 | 0.36 | NS |
PCB180 | 0.15 | 0.32 | NS | 0.1 | 0.35 | NS |
PCB187 | 0.42 | 0.33 | NS | 0.47 | 0.36 | NS |
PCB194 | 0 | 0.34 | NS | 0 | 0.37 | NS |
PCB199 | 0.38 | 0.32 | NS | 0.17 | 0.36 | NS |
PCB138/158 | 0.44 | 0.31 | NS | 0.57 | 0.34 | 4.58 × 10−2 |
PCB196/203 | 0.12 | 0.33 | NS | 0 | 0.36 | NS |
Sum PCB | 0 | 0.36 | NS | 0.09 | 0.38 | NS |
h2g, proportion of genetic variance on the total phenotypic variance; SE, standard error; NS, not significant.