Table 5. Combined effects of maternal–fetal SNPs in linear regression models.
| Combined: Maternal SNPa | Combined: Fetal SNPa | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Compound | SNP | CHR | BP | Locus | β | SE | P-Value | β | SE | P-Value |
| p,p′-DDE | rs7259965 | 19 | 41,521,532 | CYP2B6 | 0.3 | 0.05 | 4.4 × 10−9 | 0.05 | 0.05 | NS |
| BDE-99 | rs7259965 | 19 | 41,521,532 | CYP2B6 | 0.33 | 0.06 | 8.8 × 10−8 | 0.11 | 0.06 | 4.1 × 10−2 |
| BDE-28 | rs11789653 | 9 | 17,993,589 | ADAMTSL1-SH3GL2 | 0.63 | 0.12 | 4.2 × 10−7 | 0.19 | 0.12 | NS |
| PCB196/203 | rs75107653 | 3 | 4,181,811 | SETMAR-SUMF1 | 0.59 | 0.11 | 6.8 × 10−8 | 0.04 | 0.11 | NS |
| PCB187 | rs10500669 | 11 | 6,328,472 | PRKCDBP | 0.19 | 0.04 | 1.5 × 10−6 | 0 | 0.04 | NS |
| BDE-100 | rs72913475 | 18 | 44,170,156 | LOXHD1 | 0.05 | 0.1 | NS | 0.55 | 0.1 | 7.5 × 10−8 |
CHR, chromosome; BP, position; SE, standard error; NS, not significant.
a
Linear regression models adjusted for maternal birth place, maternal age, maternal education attainment, offspring gender, month of birth, parity, 10 ancestry coordinates, offspring ASD outcome status, maternal SNP genotypes, and fetal SNP genotypes.