Fig. 3. (A) Clinical signs during lithium treatment of experimental autoimmune encephalomyelitis (EAE). Animals (n=5) were euthanized at the time of peak paralysis (day 13 postimmunization [PI], arrow). (B–D) Histopathological examination of the spinal cords of rats with EAE on day 13 PI. The spinal cords of the control group showed a normal architecture (B). However, the spinal cords of vehicle-treated rats contained many inflammatory cells in the parenchyma (C), whereas there were fewer inflammatory cells in the spinal cords of lithium-treated rats (D). (B–D) Hematoxylin and eosin staining. Values are presented as mean±SE. ^**P< 0.01 vs. vehicle treatment. Scale bars=50 µm (B–D).