Table 1. p-GSK-3β immunoreactivity in the spinal cords of control and EAE-affected ratsa).
Cell type | Control | EAE | |||
---|---|---|---|---|---|
Normal | CFA control | Paralysis stage | Recovery stage | ||
G.1 | G.3 | R.0 | |||
Inflammatory cellsb) | ND | ND | + | + | + |
Astrocytes | +++ | +++ | +++ | + | +++ |
Neurons | + | + | + | + | + |
Ependymal cells | + | + | + | + | + |
Vascular endothelial cells | +++ | +++ | +++ | +++ | +++ |
p-GSK-3β, phosphorylated glycogen synthase kinase-3β; EAE, experimental autoimmune encephalomyelitis; CFA, complete Freund's adjuvant; ND, inflammatory cells were not detected in the spinal cord; +, weak; ++, moderate; +++, strong. a)Three blind observers examined three sections from each of five animals. b)Inflammatory cells included p-GSK-3β-positive T cells and macrophages.