Figure 2.

MYC-dependent miRNA regulation of glutamine metabolism. MYC was found to downregulate miR-23a/b, which targets Gls, resulting in increased production of glutamate from glutamine (Gao et al., 2009). In addition, MYC was found to upregulate miR-18a, which targets GCLC, resulting in decreased production of glutathione from glutamate, and increased flow of glutamine-derived carbon into the TCA cycle (Anderton et al., 2017). Gray lines indicate a decreased effect, and dotted lines indicate a multi-step metabolic pathway.