. 2017 Apr 11;7:122. doi: 10.3389/fcimb.2017.00122

Table 4.

MICs of tetracycline, tigecycline, macrolides (erythromycin, azithromycin) telithromycin, chloramphenicol, rifampicin and linezolid against F. tularensis.

Reference	Origin	Nb of strains Type/biovar	Tetracycline		Tigecycline		Erythromycin		Azithromycin		Telithromycin	Chloramphenicol		Rifampicin		Linezolid
			Range	MIC₉₀	Range	MIC₉₀	Range	MIC₉₀	Range	MIC₉₀	Range	Range	MIC₉₀	Range	MIC₉₀	Range	MIC₉₀
BROTH MICRODILUTION
Origgi et al., 2014	Switzerland	19 B6	≤ 0.25	≤ 0.25			2-8	4				≤ 2	≤ 2
		5 B12	≤ 0.25				>32					≤ 2
Georgi et al., 2012	Europe	69 B	≤ 0.125–2	1			1->16	>16				1–4	2	≤ 0.5–2
	North America	7 A	≤ 0.125–0.5										≤ 0.5
	Central Asia	4 ssp. mediasiatica	0.25–2									1–4
Urich and Petersen, 2008	North America	92 A	0.25–2	1			0.5–4	2				0.5–4	2
		77 B	0.12–2	1			0.5–2	0.5				0.5–4	2
E-TEST MIC STRIPS
Johansson et al., 2000	Sweden	7 B					>256					0.25		0.5
Hotta et al., 2013	Japan	36 B					0.094–1.5	1.5
Kreizinger et al., 2013	Hungary	29 B12	0.19–0.72	0.5	0.094–0.19	0.19	>256	>256				0.5–1.5	1.5	0.5–2	1	12–48	32
Yeşilyurt et al., 2011	Turkey	39 B biovar II	0.125–0.5	0.38	0.094–0.38	0.25	>256	>256	>256	>256		0.094–0.25	0.25	0.25–1	0.75	0.5–2	1.5
Tomaso et al., 2005	Austria	50 B biovar II	0.125–0.75	0.75			4->256	>256				0.023–2	0.75	0.25–3	1.5
Ikäheimo et al., 2000	Finland	38 B	0.094–0.5	0.38					>256	>256		0.125–0.5	0.38	0.094–0.38	0.25
Kiliç et al., 2013	Turkey	249 B biovar II+ 1 biovar japonica	0.094–0.5	0.38			1->256	>256				0.094–0.75	0.5	0.125–1	0.75
Johansson et al., 2002	USA	8 A					0.125–1		0.125–2			0.5–1		0.25–2		2–4
		16 B					0.125–1	1	0.064–2	1		0.25–1	1	0.125–1	1	4–16	8
Velinov et al., 2011	Bulgaria	21 B biovar II					>256	>256				1–4	2
AGAR DILUTION
Valade et al., 2008	France	71 B									0.125–0.25	0.25–2		0.015–0.5
Johansson et al., 2000	Sweden	7B										0.5–1		1