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Combined effects of AZD6244 and linagliptin on podocyte growth
| pIC50 | ||
|---|---|---|
| [Linagliptin] (nM) | Y P | Y O |
| – | 5.2 | 5.2 |
| 1 | 5.2 | 5.3 |
| 10 | 5.2 | 5.1 |
| 100 | 5.2 | 5.3 |
Immortalized human podocytes were exposed to vehicle alone, AZD6244 or AZD6244 + linagliptin for 5 days, then cell growth was evaluated. Data are the mean ± SEM of five experiments run in duplicate for each experimental group.
