Figure 1.

(A) Effect of YL‐0919, vilazodone and 8‐OH‐DPAT on [35S]‐GTPγS binding to rat hippocampal membranes. (B) Effect of WAY‐100635 on 8‐OH‐DPAT‐induced stimulation of [35S]‐GTPγS binding to rat hippocampal membranes. (C) Effect of WAY‐100635, mianserin or tropisetron on YL‐0919‐induced stimulation of [35S]‐GTPγS binding to rat hippocampal membranes. The results are expressed as the mean ± SEM. Values for the % of the respective basal binding were obtained from four experiments performed in duplicate. * P < 0.05 versus Vehicle, # P < 0.05 versus 8‐OH‐DPAT or YL‐0919 (Two‐way ANOVA followed by Dunnett's test).