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. 2017 Mar 10;174(9):781–795. doi: 10.1111/bph.13736

Figure 2.

Figure 2

EXP‐1 is differentially activated by GABA agonists. (A) Dose–response curves comparing the responses of each agonist tested normalized to maximal GABA responses (3 mM) for EXP‐1. Oocytes were voltage clamped at −60 mV, and agonists were bath applied in series (1–3000 μM) for 5 s. Due to its low potency, β‐alanine was applied in series at higher concentrations (3–300 mM). Each data point represents the mean ± SEM with n ≥ 10 and N = 4. (B) Bar graph illustrating the efficacy of compounds tested relative to maximal GABA responses (3 mM). Each bar represents the mean ± SEM with n ≥ 10. n.s, not significant (P ≥ 0.05), *P ≤ 0.05; significantly different from GABA; one‐way ANOVA, Holm–Sidak post hoc test. (C) Representative current responses from an EXP‐1 expressing oocyte with each compound tested in series at maximal dose (3 mM; β‐alanine = 300 mM). Scale bar = 1 μA, 10 s.