Figure 4.

Effect of LY2969822 on the rat capsaicin model of tactile allodynia and thermal hyperalgesia. LY2969822 was dosed at 1, 3 and 10 mg·kg⁻¹ and gabapentin at 100 mg·kg⁻¹ or AMG517 at 30 mg·kg⁻¹. Capsaicin 1.2%, 18 μg in 15 μL olive oil, was injected intraplantar 2 h post‐compounds. (A) Tactile allodynia score was measured at 15, 30 and 60 min post‐capsaicin. (B) Thermal hyperalgesia scores were measured at 0.5, 1 and 2 h post‐capsaicin. Values are mean ± SEM, n = 8–10 per group. *Indicates significantly different versus vehicle response at the corresponding time point (P < 0.05, two‐way ANOVA followed by post hoc Dunnett's test).